Journal of Shandong University of Traditional Chinese Medicine

期刊封面

Journal Title:Journal of Shandong University of Traditional Chinese Medicine
ISSN:1007-659X
CN:37-1279/R
Sponsor:Shandong University of Traditional Chinese Medicine

Reading Classics,Diligence in Clinical Practice,Valuing Inheritance,and Generating New Knowledge
DING Yuanqing;Shandong University of Traditional Chinese Medicine;
This paper reviews the author's experiences and gains in learning medicine,engaging in clinical practice,and teaching over more than 40 years,especially after participating in the first National Excellent Traditional Chinese Medicine Clinical Talents Training Course. It places special emphasis on studying and applying the classics,valuing mentorship,and generating new knowledge. One should pursue the study of classics with unremitting diligence and also conduct extensive reading to enlighten thinking. Learning for practical application is the fundamental purpose of reading classics:we should seek ideas and solutions from the classics,return to clinical practice,and verify them there. Understanding principles through reading and pursuing truth in clinical practice are the basic requirements for reading and clinical work. Without reading,clinical practice will lack theoretical guidance;inheritance and innovation are interconnected,and without innovation,current difficult problems cannot be solved. Finally,combining past experiences in reading,clinical research,and teaching,the entire process of learning and practicing medicine is summarized as “read the classics,be diligent in clinical practice,value inheritance,and generate new knowledge”.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2078K]

International Dissemination of Traditional Chinese Medicine:Historical Characteristics,Impacts and Implications
CHEN Zhan;YAO Qiuhui;International Cooperation and Exchange Office,Shandong University of Traditional Chinese Medicine;College of Foreign Languages,Shandong University of Traditional Chinese Medicine;
Since the Qin and Han dynasties,Traditional Chinese Medicine(TCM) has begun to spread to neighboring countries of China. Up to now,TCM has been disseminated to more than 190 countries and regions around the world. The international dissemination of TCM,which has lasted for thousands of years,presents historical development characteristics such as diversified dissemination channels,systematized and standardized dissemination content,expanded dissemination regions,and gradually optimized dissemination effects. The international dissemination of TCM has exerted profound impacts on TCM itself as well as foreign medical systems such as Arabian medicine and Western medicine. A systematic review of the history of TCM's international dissemination can provide profound historical implications and practical references for the current construction of TCM cultural identity,guarantee of efficacy and safety,translation standardization for TCM language,formulation of relevant laws and regulations,improvement of international cooperation mechanisms,and the innovative development of TCM.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2119K]

Application of “Xuyu Zhijie”(Fish Cultivation with Shellfish Placement) Method in Cough Variant Asthma
SHI Qianqian;ZHAN Zhaoshuang;WANG Jiafeng;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine;
Cough variant asthma(CVA) is a latent type of asthma mainly characterized by chronic cough. The cough is spasmodic and paroxysmal,accompanied by itchy pharynx,which conforms to the pathogenic characteristics of “wind pathogen” in traditional Chinese medicine(TCM),and can be classified into the categories of wind cough,asthma cough,and convulsive cough in TCM theory. CVA is protracted and refractory,with recurrent attacks and a prolonged disease course,which tends to consume genuine yin,making it a syndrome of deficiency in root cause and excess in symptom—liver-kidney yin deficiency as the root cause and manifested as floating yang hyperactivity. The underlying cause of yang hyperactivity lies in water(yin) depletion:kidney yin fails to nourish liver wood,leading to endogenous deficient wind and manifestations of stirring wind due to yin deficiency. The reversed flow of liver wind invades the lung,impairing the lung's functions of dispersing and descending,thereby inducing cough. The “Xuyu Zhijie”(fish cultivation with shellfish placement) method aims to harmonize the body's yin and yang,nourish genuine yin in the lower energizer,and subdue the hyperactive floating yang in the upper body. This paper mainly discusses the etiology and pathogenesis of CVA from the perspectives of “wind” and “deficiency”,takes nourishing genuine yin and subduing floating yang as the therapeutic principles,and applies shell-based Chinese medicinals to nourish yin and subdue yang,resolve phlegm and extinguish wind,and harmonize yin and yang,so as to extinguish wind,relieve cough,resolve phlegm and cure the disease.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2058K]

Discussion on Pathogenesis of Myocardial Ischemia-Reperfusion Injury from Perspective of Heat-Toxin Theory
JIANG Yonghao;LI Xiao;First Clinical Medical College,Shandong University of Traditional Chinese Medicine;
Myocardial ischemia-reperfusion injury(MIRI) is a major clinical challenge in cardiovascular interventional therapy,and its pathogenesis involves multiple complex processes such as oxidative stress,inflammatory response,calcium overload,and cell death,etc. Based on the heat-toxin theory of traditional Chinese medicine(TCM),this paper explores the intrinsic correlation between heat-toxin and the pathological mechanism of MIRI from two perspectives:“the complexity of MIRI” and “the correlation between heattoxin theory and the occurrence,development and treatment of MIRI”. Studies have shown that the heattoxin theory is highly consistent with the pathological manifestations of MIRI in terms of external pathogen invasion,pathogenesis evolution,and toxic damage:the excessive internal heat at the initial stage of heattoxin corresponds to the oxidative stress induced by reactive oxygen species(ROS) after reperfusion;the process of heat-toxin invading from the exterior to the interior and spreading to Zang-Fu organs is similar to the expansion of inflammatory response from the local area to the whole body;the tissue erosion and necrosis caused by heat-toxin transforming into putrefaction and toxin are consistent with cell death and irreversible myocardial injury in MIRI;the heat-clearing and toxin-removing method can play an important role in the prevention and treatment of MIRI by inhibiting oxidative stress and inflammatory response. The interpretation of pathogenesis and brief analysis of therapeutic methods based on heat-toxin theory provide a new perspective for revealing the essence of MIRI and new ideas for TCM intervention in MIRI.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2061K]

Treating Essential Thrombocythemia Based on Theory of “Pathogenic Blood Returning to Liver”
SONG Anning;LI Mingxia;MA Juning;YANG Jing;Shandong University of Traditional Chinese Medicine;Weifang Hospital of Traditional Chinese Medicine;
The theory of “pathogenic blood returning to liver” originated from LI Dongyuan's Inventions in Medicine. Essential thrombocythemia(ET) is a disease with blood stasis as the main pathological product,so resolving blood stasis is used as a symptomatic treatment. The smooth flow of qi is the prerequisite for the normal operation of human functions. Resolving blood stasis depends on smooth qi movement,and smooth qi movement relies on normal function of the liver,thus regulating the liver is regarded as the fundamental treatment. Syndrome differentiation and treatment should start from the liver. It is believed that the pathogenesis of ET is disharmony between qi and blood,intermingling of pathogenic factors and blood stasis,and stasis obstructing liver collaterals,with liver-regulating and stasis-resolving as the core therapeutic principle. According to the onset stages of ET,the disease is treated by stages with the following therapeutic methods:soothing the liver and relieving depression,regulating qi and activating blood;regulating the liver and strengthening the spleen,resolving phlegm and removing blood stasis;calming the liver and tonifying the kidney,nourishing yin and resolving blood stasis.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2065K]

Exploration of Occurrence and Progression of Depression from Perspective of “Heart-Kidney Axis System”
ZHANG Xizhen;LI Zifa;CHEN Kai;ZHENG Zhiyong;HU Minghui;WANG Xinyu;ZHANG Hao;GENG Xiwen;WEI Sheng;Key Laboratory of Classic Theory of Traditional Chinese Medicine of Ministry of Education/Shandong Provincial Key Laboratory of Innovation and Application Research of Basic Theory of Traditional Chinese Medicine/Shandong Provincial Engineering Research Center of Traditional Chinese Medicine for Prevention and Treatment of Major Brain Diseases/Jinan Key Laboratory of Traditional Chinese Medicine for P
Depression is a common mental disorder with its incidence rate and psychological disability rate increasing year by year. In traditional Chinese medicine(TCM),the liver is believed to govern emotions,and the occurrence of depression is closely related to liver qi stagnation and emotional disorder. Many modern studies also focus on the liver. However,simply differentiating and treating from the perspective of the liver is difficult to fully interpret the complex pathogenesis of depression and cannot effectively interrupt its recurrent and lingering disease process. By re-examining the pathogenesis of depression from system theory of TCM and based on the new theory of “heart-kidney axis system”,this paper sorts out the relationship between the heart and kidney from multiple dimensions. Taking the regulatory effect of the dynamic interaction between the heart and kidney on the body's qi and blood,yin and yang,and spirit as the entry point,it is proposed that the disharmony between the heart and kidney and the imbalance of the axis are important pathogenesis leading to depression,while the deficiency of Zang-Fu organs and qi-blood,over-restriction and counter-restraint,and abnormal circulation of meridians are key links in the occurrence of depression. From the perspective of the integration of traditional Chinese and Western medicine,this paper analyzes and demonstrates the relationship between the “heart-kidney axis system”,the neuroendocrine regulatory system and depression,aiming to provide new theoretical ideas and strategies for the diagnosis and treatment of depression.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 1999K]

Treatment of Insomnia Based on Theory of Qi Circulation
HU Wenjing;WANG Jiantao;WANG Yanan;LUO Chenyang;WANG Qianqian;HU Mindi;Gansu University of Chinese Medicine;Chengdu University of Chinese Medicine;Gansu Provincial Hospital of Traditional Chinese Medicine;
Based on HUANG Yuanyu's theory of “qi circulation” and Peng Ziyi's theory of “circular movement of qi”,this paper grasps the diagnosis and treatment of insomnia from an overall perspective. It holds that the core pathogenesis of insomnia lies in the failure of spleen(Ji Tu) to ascend,stomach(Wu Tu) to descend,dysfunction of the middle energizer as the hub,stagnation of qi movement,disharmony of stomach qi,insufficiency of qi and blood production,which fails to nourish the heart,leading to restlessness of the mind. Meanwhile,without blood to soften and nourish the liver,the liver loses its tenderness. The acquired foundation cannot nourish the innate foundation,so kidney essence cannot ascend to the heart,resulting in discordance between heart and kidney,disharmony of Zang-Fu organs,and failure of spirit to be housed internally,thus causing insomnia. Based on the mode of qi circulation and combined with clinical practice,this paper discusses the treatment of in-somnia,and puts forward the therapeutic principles of invigorating the spleen to replenish the source and regulating the middle energizer,supporting metal to suppress wood and regulating qi movement,reducing heart fire and tonifying kidney yin to coordinate heart and kidney. On this basis,the self-formulated Chaigui Anshen Decoction（柴归安神方） is proposed to soothe the liver and nourish blood,and strengthen the middle energizer and spleen,providing a new concept for clinical treatment of insomnia.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2003K]

Shennong's Classic of Materia Medica and Mahuang(Ephedrae Herba) in Application of Classic Formulas
PENG Xue;ZHANG Daize;BAI Xiangyu;YUAN Hongxia;Graduate School,Tianjin University of Traditional Chinese Medicine;College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine;
Mahuang(Ephedrae Herba) is one of the commonly used medicinal herbs in classic formulas. Shennong's Classic of Materia Medica describes its efficacy as “treating wind stroke,cold damage,headache and malaria,relieving warm malaria by inducing sweating,eliminating pathogenic heat,relieving cough and adverse rising of qi,expelling cold-heat pathogen,resolving abdominal lump and accumulation”. Based on the efficacy of Mahuang recorded in Shennong's Classic of Materia Medica,Treatise on Cold Damage and Miscellaneous Diseases developed concise and refined classical formulas through herbal compatibility,which still exert profound influence up to now. For example,in treating “wind stroke,cold damage and headache”,Mahuang is mostly combined with Guizhi(Cinnamomi Ramulus),Kuxingren(Armeniacae Semen Amarum),Gegen(Puerariae Lobatae Radix) and Shigao(Gyp-sum),with representative formulas such as Mahuang Decoction（麻黄汤）,Gegen Decoction（葛根汤） and Daqinglong Decoction（大青龙汤）；in relieving “warm malaria by inducing sweating and eliminating pathogenic heat”,it is mostly combined with Guizhi,Shaoyao(Paeoniae Radix) and Shigao,with Guizhi Er Yuebi Yi Decoction（桂枝二越婢一汤） as the representative formula;in relieving “cough and adverse rising of qi and expelling cold-heat pathogen”,it is mostly combined with Shegan(Belamcandae Rhizoma),Shigao,Banxia(Pinelliae Rhizoma),Xixin(Asari Radix et Rhizoma) and Wuweizi(Schisandrae Chinensis Fructus),with representative formulas including Xiaoqinglong Jia Shigao Decoction（小青龙加石膏汤）,Shegan Mahuang Decoction（射干麻黄汤）,Yuebi Jia Banxia Decoction（越婢加半夏汤） and Mahuang Xingren Gancao Shigao Decoction（麻黄杏仁甘草石膏汤）；in “resolving abdominal lump and accumulation ”,it is mostly combined with Guizhi,Fuzi(Aconiti Radix Lateralis Preparata) and Shaoyao,with representative formulas like Guizhi Shaoyao Zhimu Decoction（桂枝芍药知母汤） and Wutou Decoction（乌头汤）. While inheriting the efficacy of Mahuang from Shennong's Classic of Materia Medica,ZHANG Zhongjing also made developments and innovations,such as adding the effect of inducing diuresis to alleviate edema. When applying Mahuang,one should refer to both Shennong's Classic of Materia Medica and Treatise on Cold Damage and Miscellaneous Diseases.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2018K]

Analysis of Houpo(Magnolia Officinalis Cortex) for Treating “Qi-Blood Impediment Syndrome”
XU Yao;SUN Yumu;ZHAO Xueying;Heilongjiang University of Chinese Medicine;
Houpo(Magnolia Officinalis Cortex) has the effects of drying dampness,moving qi,resolving accumulation,and relieving asthma,and is widely used in clinical practice. Shennong's Classic of Materia Medica first recorded that Houpo is indicated for treating “qi-blood impediment syndrome”,and physicians in later generations have provided theoretical interpretations of this effect. This paper explores the origin and verifies the efficacy of Houpo in treating “qi-blood impediment syndrome” by combining the materia medica monographs such as Shennong's Classic of Materia Medica and Commentary on Shennong's Classic of Materia Medica,etc.,as well as the compatibility of formulas like Houpo Decoction（厚朴汤） and Houpo Decoction Concentrate（厚朴煎）,so as to provide guidance for clinical practice.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 1981K]

Syndrome Differentiation and Treatment of “Blood Stasis” State of Chronic Kidney Disease Based on Consumptive Injury in Four Sages' Heart Source
CHEN Shiyao;JIANG Peng;NIU Jing;CAO Yuanru;CHEN Lulu;GUO Zhenfeng;HE Liqun;GAO Jiandong;Third Clinical Medical College of Anhui University of Chinese Medicine/Department of Nephrology,Anhui Hospital of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Department of Nephrology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine/Institute of Traditional Chinese Medicine Nephrology,Shanghai University of Traditional Chinese Medicine/
“Blood stasis” is the core pathological state of chronic kidney disease(CKD),which runs through the whole course of the disease and is a key factor affecting its prognosis. Based on HUANG Yuanyu's academic thoughts in Consumptive Injury in Four Sages' Heart Source,combined with modern medical knowledge and the clinical experience of our team,this paper systematically explores the syndrome differentiation and treatment system of the “blood stasis” state in CKD. The “blood stasis” state can be seen in various syndrome types of CKD,with three syndrome types being the most typical:blood deficiency with stasis,dampness in the spleen and stagnation of the liver qi,and kidney deficiency with blood stasis. For the syndrome of blood deficiency with stasis,Guizhi Danpi Taoren Decoction（桂枝丹皮桃仁汤） combined with Dabuyuan Decoction（大补元煎） should be selected,focusing on tonifying qi and replenishing blood,promoting blood circulation to resolve stasis;for the syndrome of dampness in the spleen and stagnation of the liver qi,Zisu Jiangling Decoction（紫苏姜苓汤） with the addition of Chaihu(Bupleuri Radix) and Chuanniuxi(Cyathular Radix) should be selected,aiming at regulating qi and relieving depression,warming the spleen and removing dampness,and promoting blood circulation to remove stasis;for the syndrome of kidney deficiency with blood stasis,Poyu Decoction（破瘀汤）,Yiqi Yangyin Taohong Siwu Decoction（益气养阴桃红四物汤）,Erxian Decoction（二仙汤）,etc. are selected,emphasizing on tonifying the kidney and supplementing essence,regulating yin and yang,and promoting blood circulation to remove stasis. A framework of syndrome-differentiated treatment centered on “regulating Zang-Fu viscera and promoting blood circulation to remove stasis” is constructed,highlighting the guiding value of HUANG Yuanyu's theory of consumptive injury in the diagnosis and treatment of CKD. It provides a theoretical basis and practical reference for the clinical syndrome differentiation and treatment of the “blood stasis” state in CKD in traditional Chinese medicine,and also provides a direction for in-depth research on the combination of classic theories and modern clinical practice.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 1960K]

Mechanism of Gouteng Xuanshen Granule（钩藤玄参颗粒） in Reducing Prehypertension Based on AMPK/e NOS Signaling Pathway
WANG Jingyi;ZHAO Wenjie;LI Boyang;WANG Danyang;LI Yunlun;QI Dongmei;Institute of Innovation in Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;Shandong Provincial Key Laboratory of Basic Research on Traditional Chinese Medicine;Key Laboratory of Classic Theory of Traditional Chinese Medicine,Ministry of Education,Shandong University of Traditional Chinese Medicine;Experimental Center,Shand
Objective:To investigate the mechanisms of Gouteng Xuanshen Granules（钩藤玄参颗粒） on endothelial injury and mitochondrial dysfunction in rats with prehypertension based on the AMPK/e NOS signaling pathway. Methods:In the in vivo experiment,48 SPF-grade WKY rats were randomly divided into six groups:the normal group,model group,positive drug group(Valsartan 8 mg/kg+Atorvastatin 1 mg/kg),and low-,medium-,and high-dose Gouteng Xuanshen Granule groups(1.08,2.16,4.32 g/kg of the granule per day),with eight rats in each group. Except for the normal group,the other groups were subjected to a highsalt and high-fat diet for 8 weeks to induce the model. Following the successful modeling,the experimental groups were given the designated dosage of medicinal solution by gavage for another 8 weeks. Blood pressure was monitored every two weeks for each group. At the end of administration,a biochemical analyzer was used to detect total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C),Enzyme-linked immunosorbent assay(ELISA) was employed to determine the serum levels of adenosine triphosphate(ATP),adenosine diphosphate(ADP),and adenosine monophosphate(AMP). Hematoxylin-eosin(HE) staining was performed to observe the pathological changes of the aorta;immunofluorescence was used to detect endothelial cell viability;and Western blot(WB) was applied to analyze the protein expression levels of adenosine monophosphate-activated protein kinase(AMPK),phosphorylated adenosine monophosphate-activated protein kinase(p-AMPK),endothelial nitric oxide synthase(e NOS),and phosphorylated endothelial nitric oxide synthase(p-e NOS). For the in vitro experiment,endothelial cells were divided into the normal group,model group,and medicated serum group of Gouteng Xuanshen Granules. Tetramethylrhodamine methyl ester(TMRM) probe was used to detect the mitochondrial membrane potential of endothelial cells. Dichlorodihydrofluorescein diacetate(DCFH-DA) probe was utilized to measure reactive oxygen species(ROS) in cells. ATP assay kit was adopted to determine the changes of ATP content in endothelial cells. Mito-tracker Green combined with Mito SOX probe was used for the joint detection of mitochondrial ROS in endothelial cells;and WB was performed to detect the protein expression levels of p-AMPK and p-e NOS in endothelial cells. Results:In vivo experimental results showed that compared with the model group,the blood pressure of rats in the Gouteng Xuanshen Granule groups decreased significantly(P<0.05). In the Gouteng Xuanshen Granule groups,the four blood lipid indexes tended to be normal,the contents of ATP,AMP,and ADP increased(P<0.05,P<0.01). HE staining results indicated that the aortic endothelial morphology of rats in the Gouteng Xuanshen Granule groups was restored,and immunofluorescence results showed that endothelial cells in the Gouteng Xuanshen Granule groups were arranged neatly with reduced shedding. In vitro experimental results demonstrated that compared with the model group,the medicated serum group of Gouteng Xuanshen Granules had improved scratch healing ability,increased average fluorescence of membrane potential,decreased ROS and mitochondrial ROS,elevated ATP content,and up-regulated protein expressions of p-AMPK and p-e NOS,with statistically significant differences(P<0.05,P<0.01). Conclusion:Gouteng Xuanshen Granules can reduce hypertension caused by endothelial injury by regulating the AMPK/e NOS signaling pathway and improve mitochondrial dysfunction.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2661K]

Study on Effect and Mechanism of Lichong Shengsui Decoction（理冲生髓饮） in Treating Ovarian Cancer
YU Yang;LI Shiying;HAN Fengjuan;Postdoctoral Research Station,Heilongjiang University of Chinese Medicine;First Affiliated Hospital,Heilongjiang University of Chinese Medicine;Shaoxing Maternal and Child Health Hospital;
Objective:To explore the relevant molecular mechanism of Lichong Shengsui Decoction（理冲生髓饮） exerting anti-ovarian cancer(OC) effects by regulating the nuclear factor-κB(NF-κB) pathway mediated by tripartite motif-containing protein 44(TRIM44). Methods:Human ovarian cancer SKOV3 cells with stable overexpression of TRIM44 were constructed,and the cells were subcutaneously inoculated into Balb/C nude mice to establish a xenograft tumor model. A total of 40 nude mice were randomly divided into the blank group,cisplatin group,Chinese medicinal group,and combination group,with 10 mice in each group. The Chinese medicinal group was given Lichong Shengsui Decoction at a dose of 7.52 g/kg by gavage twice a day. The cisplatin group was intraperitoneally injected with 0.1 mg/mL cisplatin solution every other day. The combination group was given Lichong Shengsui Decoction at 7.52 g/kg by gavage twice a day,combined with intraperitoneal injection of 0.1 mg/mL cisplatin solution(equivalent to 3 mg/kg) every other day. The blank group was given an equal volume of normal saline by gavage twice a day. After 14 days of drug intervention,the tumor volume and growth trend of nude mice were observed. Hematoxylin-eosin(HE) staining was used to observe the histopathological changes of tumor tissues. Reverse transcription-polymerase chain reaction(RT-PCR) was employed to detect the mRNA expressions of inhibitor of κB kinase β(IκKβ),nuclear factor-κB inhibitorα(IκBα),and nuclear factor-κB p65(NF-κB p65) in tumor tissues. Double immunofluorescence staining was used to detect the distribution of TRIM44 and NF-κB p65 proteins in tumor tissues. Western blot(WB) was applied to determine the differences in the protein expressions of TRIM44,IκKβ,IκBα,phosphorylated nuclear factor-κB inhibitor α(p-IκBα),NF-κB p65,B-cell lymphoma-2(Bcl-2),matrix metalloproteinase-9(MMP-9),cysteinyl aspartate-specific protease 3(Caspase3),and vascular endothelial growth factor(VEGF) in tumor tissues. Results:Compared with the blank group,the cisplatin group,Chinese medicinal group,and combination group all inhibited the growth of ovarian cancer xenografts in nude mice. All medication groups were able to reduce the mRNA expressions of IκKβ and NF-κB p65 in tumor tissue,and up-regulate the mRNA expression of IκBα in tumor tissues,with the most significant difference in the combination group(P<0.05). All medication groups significantly decreased the protein expressions of TRIM44,IκKβ,p-IκBα,NF-κB p65,Bcl-2,MMP-9,VEGF,and increased the protein expressions of IκBα and Caspase-3 in tumor tissues,with the most prominent effect in the combination group(P<0.05). Conclusions:Lichong Shengsui Decoction can inhibit the growth of ovarian cancer xenografts in nude mice and enhance anti-tumor effects in combination with cisplatin. Its mechanism may be related to down-regulating the expression of TRIM44,inhibiting the activation of the NF-κB signaling pathway,thereby suppressing the invasion and metastasis of ovarian cancer and promoting its apoptosis.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2373K]

Study on Morphological and Microscopic Identification of Leaves from Three New Varieties and Wild Species of Ziziphus Jujuba Var. Spinosa
ZHANG Suzhen;GUO Qingmei;MA Yan;DU Xianchen;ZHAO Hongyan;Shandong University of Traditional Chinese Medicine;Jinan Academy of Agricultural Sciences;Jinan Zijin Rose Co.,Ltd.;
Objective:To conduct morphological and microscopic identification of leaves from three new varieties(Pufeng No.1,Pufeng No.2,Pusuan No.6) and the wild species of Ziziphus jujuba var. spinosa,and to provide a reference for their identification,development and utilization. Methods :Morphological,micromorphological and microscopic identification methods were adopted to observe and compare the leaf characteristics of the three new varieties and wild species of Ziziphus jujuba var. spinosa. Results:Morphological and micromorphological identification showed that there were significant differences in leaf shape,texture,pubescence on leaf veins,and stipule morphology among the three new varieties and the wild species of Ziziphus jujuba var. spinosa. Transverse section microscopic identification revealed obvious differences in the prominence of main and lateral veins,vascular bundle characteristics,and the number of mucilage cavities of the leaves. Leaf epidermis microscopic identification indicated that indices such as palisade-to-epidermis ratio,vein islet number,and stomatal density showed statistically significant differences among most varieties(P<0.05). In powder microscopic identification,non-glandular hairs,calcium oxalate cluster crystals,and vascular bundles were observed in all samples,but their sizes and distributions varied. Conclusions:Morphological,micromorphological and microscopic identification methods can effectively distinguish the three new varieties from the wild species of Ziziphus jujuba var. spinosa,which can provide a scientific basis for the identification and resource development of new varieties of Ziziphus jujuba var. spinosa.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 3244K]

Interpretation of Ziwan(Asteris Radix Et Rhizoma) Based on Pharmacological Method State
WANG Jinglong;LIU Yuliang;Zhejiang University of Traditional Chinese Medicine;
Image thinking,as the core cognitive paradigm of the theoretical system of traditional Chinese medicine(TCM),has unique value in explaining Chinese medicinal properties. Taking the pharmacological method state as the theoretical framework,this paper systematically analyzes the phenological characteristics(shape,color,property,flavor,form,and texture) and spatio-temporal attributes(growth habitat and harvesting time) of Ziwan(Asteris Radix Et Rhizoma),and constructs the mapping relationship between its “natural manifestation-medicinal state-pharmacological effect” through the cognitive path of “images abstracting from observing-interpreting the medicine by images”. The study found that Ziwan is mild in nature with the properties of acridity to disperse and bitterness to descend. Its purple color and moist texture enable it to enter the blood system. Its soft form and dissipating property can disperse and facilitate. It is harvested in autumn(corresponding to the metal phase in the five-element theory) and thus embodies the virtue of purifying and descending. This medicinal state characteristic forms a coherent theoretical and practical system with its clinical effects such as relieving cough and asthma,and promoting defecation and urination.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2001K]

Study on Relationship Between Liver-Orifice Theory and Five-Wheel Theory in Formulas from Benevolent Sages
SONG Jianing;LI Yunfeng;LI Likang;LIU Juhai;Shandong University of Traditional Chinese Medicine;
The period when Formulas from Benevolent Sages was compiled was a key node in the transformation of traditional Chinese medicine(TCM) ophthalmology theory from the liver-orifice theory to the five-wheel theory. On the basis of sorting out the development evolution of the liver-orifice theory and the five-wheel theory,this paper conducts a comparative study on the etiology and pathogenesis,syndrome differentiation and treatment system,and characteristics of formulas and medicinals for treating ophthalmopathy based on the two theories in Formulas from Benevolent Sages. It is believed that under the influence of the historical background of TCM ophthalmology becoming an independent discipline in the Song Dynasty and the introduction of Indian medicine,the two theories showed a relationship of mutual enlightenment,integration and common development. Formulas from Benevolent Sages introduced and drew on the “wheel-position-organ” model of the five-wheel theory from previous generations,and initially formed the “wheel-organ syndrome differentiation and treatment” system of ophthalmic five-wheel theory,which effectively promoted the transformation of ophthalmic syndrome differentiation and treatment from the liver-orifice theory to the five-wheel theory.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2041K]

Influence of Incense Culture on Traditional Chinese Medicine During Wei,Jin,Southern and Northern Dynasties
LIU Kang;MENG Xi;YANG Jinping;Shandong University of Traditional Chinese Medicine;
During the Wei,Jin,Southern and Northern Dynasties,with the continuation and extension of the Silk Road,the trade of aromatic medicines flourished remarkably. As a result,aristocrats and literati not only widely used aromatic medicines in daily life,but also formed an incense-admiring culture in terms of aesthetic orientation,values,and cultural guidance. Meanwhile,the religious incense-worshipping culture and folk incense custom culture were also quite prosperous. Incense culture integrated into people's daily life and profoundly changed the social outlook. Its prosperity shaped the theories and thoughts of traditional Chinese medicine(TCM) in this period. It not only enriched the types of aromatic medicine applications,deepened the understanding of their medicinal properties,and promoted the development of Chinese materia medica,but also exerted a far-reaching influence on the innovation of aromatic therapy methods and dosage forms in medical practice,the construction and improvement of TCM cosmetology methods,and the advancement of TCM thoughts on epidemic prevention and treatment. In-depth exploration of TCM thoughts and methods influenced by incense culture in the Wei,Jin,Southern and Northern Dynasties has certain guiding value for the clinical practice of modern TCM aromatic therapy.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 1984K]

Textual Research on Origin,Evolution and Connotation of Disease Name “Dizziness”
ZHAO Shoujie;JI Chenlu;XIANG Guangxin;SONG Yongmei;Institute of Literature and Culture,Shandong University of Traditional Chinese Medicine;Qiqihar Dongfang Hospital of Traditional Chinese Medicine Co.,Ltd.;
Dizziness refers to a disease mainly manifested by blurred vision and head spinning. There are many relevant disease-related terms in ancient books of all dynasties,and there are phenomena of the same name with different meanings and different names with the same meaning. By sorting out relevant materials,this paper clarifies the historical context of the evolution of the connotation of the disease name. In the Han Dynasty,“dizziness of the eyes”(visual changes) and “dizziness of the head”(self-feeling of spinning) were classified into two categories,and treatment was based on wind,which had a profound impact on later generations. From the Wei,Jin Dynasties to the Sui and Tang Dynasties,the experience of acupuncture treatment and Daoyin rehabilitation for “wind-induced dizziness of the head” is worthy of further exploration and research. In the medical books of the Song Dynasty,a special chapter on dizziness appeared,establishing a systematic theoretical system of etiology,pathogenesis,syndrome differentiation,and treatment. Doctors in the Jin and Yuan Dynasties advocated treatment based on wind-fire and phlegm,and innovatively proposed treatment according to body shape,which still has important guiding value for current clinical practice. The discussion on the connotation of dizziness originating from the Ming and Qing Dynasties provides important reference for the scientific definition and standard construction of the modern connotation of dizziness.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 1922K]

Analysis of Medicinal Processing Methods in Bamboo and Silk Manuscripts from Pre-Qin to Han Dynasties
WEN Xin'er;XIONG Yiliang;DUAN Xiaohua;School of Ancient Chinese Studies,Beijing University of Chinese Medicine;
Medicinal processing is a pharmaceutical technique adopted according to the theory of traditional Chinese medicine,based on the properties of medicinal materials and clinical application needs. The processing literature preserved in the unearthed bamboo and silk manuscripts are very important for studying the early medicinal processing methods. In this study,the medicinal processing methods from the Pre-Qin to the Han Dynasties are divided into six categories for analysis:cutting and trimming methods,water processing methods,drying methods,heating methods,processing with liquid excipients,and mixing methods. The study found that the medicinal processing methods in the bamboo and silk manuscripts from the Pre-Qin to the Han Dynasties were diverse and complex. The operation specifications had begun to take shape. The processing practice reflected the early understanding of the efficacy of medicines,and processing tools were already in common use.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2024K]

Research Progress on Traditional Chinese Medicine Regulating Iron Homeostasis for Treatment of Cerebral Ischemia-Reperfusion Injury
YUAN Xin;XU Haoqun;ZHAO Minghui;WANG Yuan;Shandong University of Traditional Chinese Medicine;Shandong Provincial Collaborative Innovation Center for Classic Chinese Medicine Prescriptions;
Ischemic stroke is a common form of stroke in clinical practice. Thrombectomy and thrombolysis within the time window are considered the most effective treatment strategies. However,most patients are difficult to be intervened within the time window. When treated outside the time window,cerebral ischemiareperfusion injury(CIRI) caused by blood reperfusion is inevitable. In recent years,studies have found that abnormal iron metabolism and accumulation are closely related to CIRI. Traditional Chinese medicine has the advantages of multi-targets and multi-pathways. From the perspective of iron homeostasis,this paper reviews the concept and mechanism of iron homeostasis,as well as the research on traditional Chinese medicine intervening in iron metabolism,reducing the generation of reactive oxygen species,anti-lipid peroxidation,and activating defense signaling pathways to maintain iron homeostasis,in order to provide new treatment ideas and methods for CIRI. There are 45 references in this paper.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2000K]

Research Progress on Antitumor Effects of Jixueteng (Spatholobi Caulis) and Its Active Components
DAI Wei;LI Feicui;TANG Haijun;XIAO Danting;LUO Kai;LIAO Shijie;LIU Yun;Department of Spinal Orthopedics,First Affiliated Hospital of Guangxi Medical University;Collaborative Innovation Center for Regenerative Medicine and Medical Biological Resources Development and Application,Guangxi Medical University;
Jixueteng(Spatholobi Caulis) has the effects of promoting blood circulation and enriching blood,regulating menstruation,and relaxing tendons and activating collaterals in traditional Chinese medicine. Modern studies have shown that it possesses various pharmacological activities such as antitumor,antiviral,and promoting hematopoietic function. The antitumor mechanisms of Jixueteng involve blocking cell cycle,promotion of tumor cell apoptosis,inhibition of tumor metastasis,etc. This paper systematically reviews the antitumor mechanisms of Jixueteng and its active components including flavonoids,phenolic acids,terpenoids,and sterols,such as inducing tumor cell apoptosis,inhibiting proliferation and metastasis,and blocking cell cycle. The paper also summarizes the application status of compound prescriptions of Jixueteng in tumor treatment,providing a theoretical basis for its further development and clinical application. Total 43 references are cited.
2026 01 v.50;No.278 [Abstract][OnlineView][Download 2072K]

2026 01 v.50;No.278 [Abstract][OnlineView][Download 1453K]

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