Journal of Shandong University of Traditional Chinese Medicine

期刊封面

Journal Title:Journal of Shandong University of Traditional Chinese Medicine
ISSN:1007-659X
CN:37-1279/R
Sponsor:Shandong University of Traditional Chinese Medicine

Current Contents

Medicine Carrying Dao and Dao Manifested via Medicine:On Relationship Between Yi-ology,Confucianism,Taoism,Buddhism and Traditional Chinese Medicine
ZHANG Qicheng;XIONG Yiliang;School of Chinese Classics,Beijing University of Chinese Medicine;Institute of Yi-ology,Confucianism,Buddhism,Taoism and Traditional Chinese Medicine,Beijing University of Chinese Medicine;
This paper explores the profound connections between the Yi-ology,Confucianism,Taoism,Buddhism and traditional Chinese medicine(TCM),revealing how TCM,as an important carrier of Chinese culture,integrates the essence of various ideological systems to form a unique medical system. The core connection between the Yi-ology and TCM lies in the “image-number” thinking rather than merely the “image” thinking. TCM is an application of the Yi-ology's image-number model. Confucianism and TCM share a high degree of consistency in the values of “kindheartedness” and the “benevolence” ontology,and the development of the Confucian physician group has promoted the integration of medicine with ethics and philosophy. Taoism has enriched TCM's view of life through health-preservation practices and the theory of “essence,qi,and spirit” in the Daoist alchemy,and has been highly integrated with TCM. Buddhism has provided TCM with methods for psychological adjustment,emphasizing the harmony of the mind and body. This paper proposes the viewpoint of “medicine carrying the Dao,and the Dao manifested via medicine”,arguing that the essence of TCM is “culture as the essence,medicine as the application”,and the value pursuit of TCM,“following the laws of yin and yang and harmonizing with the techniques and numbers”,embodies the “Dao” of Chinese culture's “yin-yang harmony”. TCM is not only a “technique” for treating diseases and saving lives,but also the “Dao” of Chinese civilization.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 2157K]

Inheritance and Innovation:Reflections on Research of Traditional Chinese Medicine Culture in Shandong
LIU Peng;School of Basic Medicine,Guangzhou University of Chinese Medicine;
Taking the study of Confucian physician and Bianque in the “Three Signature Cultural Icons” of Shandong's traditional Chinese medicine(TCM) culture as an example,this paper explores pathways for groundbreaking innovations in regional TCM culture research. It argues that paradigm shifts in research methodology and the critical excavation of historical texts constitute dual imperatives for future breakthroughs. Regarding Confucianism-TCM interplay,research must transcend superficial textual comparisons to delve into their profound interactions through multidimensional perspectives,encompassing social evolution,cultural traditions,and way of thinking. For Bianque's medical culture,the foundational imperative lies in reconstructing and collating his scattered medical corpus. Only by establishing this rigorous philological groundwork — through comparative analysis of Bianque 's corpus with excavated manuscripts of medical techniques,received texts such as the Huangdi's Canon of Internal Medicine and other Qin-Han medical writings — can we authentically reinterpret his historical status as the “Paragon of Medical Techniques” and redefine the intellectual history of Chinese medicine during the Qin-Han period.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1867K]

Realization of Humanistic Modernization of Traditional Chinese Medicine via Hermeneutic-Phenomenological Approach
JIAO Jianyang;ZHANG Fengcong;Institute of Chinese Medical Literature and Culture,Shandong University of Traditional Chinese Medicine;
Traditional Chinese medicine(TCM) is a practical science with both natural and humanistic attributes. It possesses a distinctive discourse system,disciplinary framework,and academic paradigm that have evolved from the traditional Chinese studies of classics and historiography. Consequently,in the course of its modernization,both naturalistic and humanistic approaches should be adopted. From the perspective of hermeneutics-phenomenology,it can be discerned that the Huangdi 's Canon of Internal Medicine is grounded in the hermeneutic circle among “ the meaning expressed by the sages-scriptures-meaning understood by physicians”. With the interpreter serving as an intermediary,the scriptures are rendered accessible to the principles of heaven and earth,yin and yang,the four seasons,and clinical practices,thereby establishing methodological herme-neutics as a crucial foundation of TCM. Further-more,TCM's interpretation of all entities in the universe centered on the concept of “qi” endows its ontology with the ideological features inherent in hermeneutics-phenomenology. It is posited that the ontology and methodology of hermeneutics-phenomenology may offer a humanistic pathway that conforms to the development laws of TCM for its modernization.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1875K]

Exploration of Pathogenesis and Intervention Ideas of Post-Stroke Symptoms Based on Theory of “Brain as Residence of Original Spirit”
DING Yuanqing;Shandong University of Traditional Chinese Medicine;
Guided by the theories of “the brain as the residence of the original spirit” and “vessel damage affecting the brain”,this paper expounds that the damage to brain marrow,the involvement of the original spirit,and the subsequent impairment to the six meridians,zang-fu organs,meridians,nutrient-defense,qi and blood constitute an interconnected pathogenic process of “mutual impairment once damaged” after stroke. It puts forward the concepts of prevention,treatment,and rehabilitation after stroke,including “mutual impairment between zang-organs and the brain”“concurrent disease of zang-organs and the brain”“ joint protection of zang-organs and the brain”“simultaneous treatment of zang-organs and the brain”.(1)Zangorgan diseases damaging the brain:the disturbance of qi transformation in the six meridians and the stagnation-induced damage to the blood vessels of the six meridians form the basis for the onset of stroke,while vessel damage affecting the brain is the core pathogenesis.(2)Brain disease damaging zang-organs:the brain has the functions of regulating the human body's qi movement and qi transformation,the stroke-induced brain damage affects the qi movement and qi transformation of the six meridians,which is referred to as “brain disease damaging zang-organs”.(3)Self-damage of brain marrow:pathological changes of self-damage to brain marrow occur after stroke. After stroke,the six meridians,zang-fu organs,and brain marrow mutually impair each other,which is called mutual impairment between zang-organs and the brain and concurrent disease of zang-organs and the brain. A series of symptoms centered on stroke thus occur,which is termed “stroke+”. The rescue of the brain after stroke starts with regulating the six meridians. Guided by regulating qi and restoring vessels,the principles for the prevention and treatment of “stroke+” are simultaneous treatment of zang-organs and the brain,joint protection of zang-organs and the brain,and rescuing the brain and soothing the spirit.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1967K]

Physiological and Pathological Traits of People with Earth-Element Constitution and Clinical Experience from Perspective of Systematic Sphygmology for Pattern Differentiation
MI Chuanhao;YI Yunhao;ZHAO Weijie;WANG Ziyue;TENG Jing;QI Xianghua;Shandong University of Traditional Chinese Medicine;Hunan University of Traditional Chinese Medicine;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;
Constitution refers to the inherent traits of the human body shaped by both innate and acquired factors,governing susceptibility to diseases and their developmental tendency. Grounded in the five-element constitution theory from the Huangdi's Canon of Internal Medicine,this study employs systematic sphygmology for pattern differentiation as the primary methodology for constitutional typing,investigates the earth type's physiological traits in terms of physical signs,personality profiles,seasonal adaptability,qi-blood equilibrium states,pulse manifestations,and its disease predispositions. Concurrently,it elucidates the pathological pulse signatures of earth-typespecific disorders and documents targeted pharmaco-therapeutic protocols. These findings aim to facilitate clinical identification of earth-type constitution,guide clinical medication,and enhance therapeutic outcomes. One illustrative case is appended.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1871K]

Analysis of Formula and Syndrome of Lianmei Decoction(连梅汤) in Detailed Analysis of Epidemic Warm Diseases and Its Modern Clinical Application
ZHANG Wenli;WANG Peng;BU Feifei;College of Traditional Chinese Medicine ,Anhui University of Chinese Medicine;Key Laboratory of Xin'an Medicine,Ministry of Education,Anhui University of Chinese Medicine;College of Humanities and International Education Exchange,Anhui University of Chinese Medicine;
Lianmei Decoction（连梅汤） was created by WU Tang in the Qing Dynasty. It is an important formula for treating the syndrome of yin damage in the late stage of summer heat,but its formula-syndrome system has not been systematically sorted out. By referring back to the original text of Detailed Analysis of Epidemic Warm Diseases and combining with relevant medical records of YE Tianshi,this paper analyzes the formula-syndrome of Lianmei Decoction,and clarifies that it is mainly used for treating consumptive thirst due to summer heat invading Shaoyin and paralysis due to summer heat invading Jueyin. The core pathogenesis is hyperactivity of heart fire and yin deficiency of liver and kidney. In terms of formula composition,Lianmei Decoction is based on the five herbs :Wumei(Mume Fructus),Huanglian(Coptidis Rhizoma),Shengdihuang(Rehmanniae Radix),Maidong(Ophiopogonis Radix),and Ejiao(Asini Corii Colla). According to the rules of formulation,the similar formulas of Lianmei Decoction can be refined into four formulation methods,namely the method of sour-bitter-sweet-pungent [the representative formulas are Jiaomei Decoction（椒梅汤） and Wumei Pill（乌梅圆）],the method of sour-sweet for nourishing yin [the representative formulas are Shengmai Powder（生脉散）,Renshen Wumei Decoction（人参乌梅汤）,and Dongyuan Qingshu Yiqi Decoction（东垣清暑益气汤）],the method of sour-bitter for clearing heat [the representative formula is Guadi Powder（瓜蒂散）],and the method of sweet-bitter combination [the representative prescription is Dongdi Sanhuang Decoction（冬地三黄汤）]. In addition to being used for summer heat invading Shaoyin and Jueyin in the late stage of summer heat,Lianmei Decoction can be flexibly used for various diseases such as spleen and stomach diseases,diseases of qi,blood and body fluids,and emotional diseases,achieving the effect of treating different diseases with the same therapy,and providing more ideas for the clinical treatment of diseases.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1952K]

Syndrome Differentiation and Treatment of Refractory Depression Based on “Concept of Constant Movement and Opposition” Between Fire and Primordial Qi
WANG Zhe;LI Liangsong;WEI Sheng;School of Chinese Classics,Beijing University of Chinese Medicine;Scientific Research Office,Shandong University of Traditional Chinese Medicine;
The concept of constant movement is an important guiding ideology in traditional Chinese medicine. This study explores the pathogenesis,syndrome differentiation and treatment regularities of LI Dongyuan's theory of primordial qi and yin-fire from the holistic perspective of “concept of constant movement and opposition” and inspires the diagnosis and treatment of refractory diseases today. Refractory depression shows the characteristics of intractable,complicated and recurrent severe diseases. The key to the evolution of its pathogenesis lies in the intense struggle between pathogenic factors and healthy qi,the intense rise and fall,and the imbalance of opposition and restriction between fire and primordial qi. According to the different key points of pathogenesis such as mixed fire,reversed fire,stagnated fire and accumulated fire,targeted treatment methods such as tonifying primordial qi,regulating primordial qi,subduing primordial qi and dredging primordial qi are adopted,in order to achieve a harmonious state where the primordial qi is sufficient and the yinfire is subdued,thereby enhancing the therapeutic effect of refractory depression.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1851K]

Syndrome Differentiation and Treatment of Parkinson's Disease Based on Theory of Latent Pathogen-Imbalance of Qi and Fire
ZHANG Jiakang;YU Xinlang;CUI Qi;LIU Xiaoyu;XU Chengcheng;LU Yan;Graduate School ,Nanjing University of Chinese Medicine;Department of Neurology,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine;
The clinical symptoms of Parkinson 's disease are complex and diverse,and its pathogenesis remains a hot-topic of current discussion. By sorting out the connotations,potential relationships of the three major theoretical systems in traditional Chinese medicine,namely latent pathogens,yin fire,and the circulation of qi,as well as their associations with the occurrence and development of Parkinson's disease,it is considered that yin fire is the core pathogenesis of the occurrence and development of Parkinson's disease;latent pathogens are the basis for the generation of yin fire and the root cause of Parkinson's disease;the circulation of qi indicates the potential direction of disease development,which is summarized as “imbalance of qi and fire”. Based on this,a theoretical model of the pathogenesis of Parkinson's disease,“latent pathogen-imbalance of qi and fire”,is proposed. It is believed that the cause of Parkinson's disease is the latent pathogens inside the body,which develop over time;the pathogenesis is yin deficiency with excessive fire,and the evolution process includes weakness of the middle-energizer,yin fire invading spleen,insufficiency of liver and kidney,yin deficiency with excessive fire,disharmony between water and fire,disharmony between the heart and kidney,deficiency of lung yin,and failure of lung qi in dispersion and descent. Treatment should be carried out from aspects such as invigorating the middle-energizer and replenishing qi,nourishing stomach yin,nourishing water to moisten wood and nourishing yin to reduce fire,coordinating the heart and kidney and tranquilizing mind,promoting the mutual generation of metal and water,regulating yin and yang.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1912K]

Exploration of Pathogenesis,Syndrome Differentiation and Treatment of Membranous Nephropathy from Perspective of “Impaired Blood Circulation Leading to Water Retention”
KANG Yi;JIN Qian;ZHOU Mengqi;LIU Yuning;LI Danwen;WANG Yaoxian;LYU Jie;Dongzhimen Hospital,Beijing University of Chinese Medicine;Beijing University of Chinese Medicine;Beijing Puren Hospital;
Membranous nephropathy(MN) is frequently characterized by hypercoagulability as a key pathological feature and edema as the primary clinical manifestation. The associated traits of slowed blood flow and increased thrombotic tendency under hypercoagulable conditions align with the pathogenesis described in traditional Chinese medicine(TCM) as “impaired blood circulation”,which denotes a propensity for stasis and stagnation. This paper explores the relationship between hypercoagulability and edema in MN through the TCM principle “impaired blood circulation leads to water retention”. We propose that the mutual binding of water and blood stasis constitutes the core pathogenesis underlying MN's development. In treatment,the methods of “invigorating spleen and tonifying kidney to nourish blood and water,removing blood stasis and dredging collaterals to activate blood circulation,and dredging triple energizer to promote diuresis” are adopted to simultaneously regulate blood and water,taking into account both strengthening healthy qi and expelling pathogenic factors,so as to achieve the purpose of activating blood circulation and promoting diuresis without damaging yin and without causing bleeding,providing novel perspectives for TCM-based MN prevention and treatment.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1939K]

Efficacy of Fuling(Poria) in “Calming Ethereal Soul and Nourishing Spirit”
GAO Shengning;YUAN Guodong;CHEN Suzhi;TAN Jinchuan;REN Meifang;Hebei University of Traditional Chinese Medicine;First Affiliated Hospital of Hebei University of Traditional Chinese Medicine;
Both ethereal soul and spirit belong to the theoretical system of the “five spiritual zang-organs” in the Huangdi's Canon of Internal Medicine,although both ultimately fall under the category of “heart governing the mental activities”. Calming ethereal soul is a method of nurturing spirit,with nurturing and tranquilizing mind are the ultimate goals. Fuling(Poria) can calm ethereal soul because it embodies wood element and possesses the characteristic of yang transforming qi. Taking the efficacy of “calming ethereal soul and tranquilizing mind” as a starting point,this paper analyzes the source of medicinal effects of Fuling and reveals its potential mechanisms of action. Fuling has a rising tendency within its descending property. Through the comprehensive effects of expelling pathogenic factors and promoting diuresis,invigorating spleen and ascending yang to replenish heart qi,tonify heart blood,nourish heart yin,and subduing heart-mind,it finally achieves the effect of calming soul and tranquilizing mind.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1854K]

Syndrome Differentiation and Treatment of Sepsis and Its Complications Based on “One Qi Circulation,Earth as Pivot with Four Elements”
LI Wanping;ZHOU Min;XU Huaimin;YU Xiaohan;CHEN Zhuoqing;FANG Lianghao;LIU Qiujiang;Fifth Clinical Medical College of Guangzhou University of Chinese Medicine;Guangdong Second Traditional Chinese Medicine Hospital;
As one of the common critical illnesses,sepsis is highly susceptible to inducing secondary complications,including multiple organ failure,circulatory disorders,capillary leakage,and septic shock. The underlying pathogenesis associated with sepsis and its complications remains complex. In his work Four Sages on the Source of Life,HUANG Yuanyu put forward the theory of “one qi circulation,earth as pivot with four elements” to elaborate on the etiology and pathogenesis of disease progression. The pivoting function of the middle earth(corresponding to spleen and stomach in traditional Chinese medicine) constitutes the core essence of one qi circulation,while the ascending on the left and descending on the right represents the fundamental pattern governing one qi circulation. The theory of “one qi circulation,earth as pivot with four elements” is closely correlated with the onset of sepsis and its complications. The core pathogenesis include deficiency of the middle-energizer and dampness in spleen,abnormal ascending on the left and descending on the right,obstruction of sweat pores by phlegm,blood stasis,and toxins,as well as yang deficiency and yin excess. Therefore,the correction of this pathological state serves as the key to the treatment of sepsis and its complications. On the basis of the aforementioned theory,this article proposes that in clinical practice,it is essential to identify the cause based on syndrome differentiation,and select therapeutic methods such as draining water and supplementing fire,supporting yang to suppress yin,regulating qi movement,resolving phlegm,blood stasis and toxins,warming yang while subduing yang to restore the normal physiological state of “one qi circulation,earth as pivot with four elements”,aiming to provide novel insights and methods for the clinical diagnosis and treatment of this disease.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1914K]

Application of Yougui Pill（右归丸） in Osteoporosis Based on Liver-Kidney-Vital Gate System
ZHANG Yu;HE Mengyuan;MIAO Wanting;GUO Zhonghua;ZHANG Zhongbo;YANG Shaoxiang;WANG Yunfei;WANG Shangzeng;Henan University of Chinese Medicine;Henan Province Hospital of Traditional Chinese Medicine;
The “liver-kidney-vital gate system” serves as a pivotal hub regulating the endocrine functions of the body,playing a critical role in maintaining endocrine homeostasis. Guided by the essence of this system,this paper delves into the pathological mechanisms of osteoporosis. It is pointed out that its root cause lies in the deficiency of kidney essence and the decline of vital gate fire,failing to warm and nourish bones by essence and blood,gradually resulting in bone loss. The superficial syndromes include liver qi stagnation,failing to maintain free movement,which causes inadequate blood supply to the bones and obstruction of tendons and vessels. Among these,the root cause is deficiency,permeating the entire disease process. Therefore,clinical treatment must emphasize tonifying kidney essence,incorporating yang-supporting principles within yin-nourishing therapies to reinforce vital gate fire,thereby achieving the goal of strengthening kidneys and bones. For the superficial excess syndromes due to failure of liver qi in free movement,methods such as soothing liver to relieve depression,nourishing blood,and enriching yin should be adopted to regulate liver and address the superficial manifestations. Accordingly,Yougui Pill（右归丸） can be employed as a foundational formula in clinical practice. Its actions of warming kidney yang,replenishing essence,and nourishing marrow align precisely with the the etiology and pathogenesis of osteoporosis. However,given the variability of clinical presentations,flexible modifications based on this formula are essential to achieve syndrome differentiation and precise therapeutic outcomes.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1894K]

Exploring the Mechanism of Xiaoshuan Tongmai Decoction（消栓通脉汤） in Treating Deep Vein Thrombosis Based on the Effect of JAK1/STAT1 Signaling Pathway on Dendritic Cell Pyroptosis
CHU Chu;AI Shuang;ZHANG Yunhong;FAN Nannan;WANG Yurou;LI Xia;WANG Bin;Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine;
Objective:To explore the mechanism of Xiaoshuan Tongmai Decoction（消栓通脉汤） regulating the janus kinase 1/signal transducer and activator of transcription 1(JAK1/STAT1) signaling pathway to alleviate dendritic cell(DC) pyroptosis in treating deep vein thrombosis(DVT). Methods:A total of 20 C57 BL/6J mice were selected to establish a mouse DVT model using inferior vena cava(IVC) stenosis method. They were then randomly divided into a model group,a low-dose group of Xiaoshuan Tongmai Decoction,a high-dose group of Xiaoshuan Tongmai Decoction,and a western medicine group,with 5 mice in each group. Each drug-treated group was given corresponding drug intervention by gavage and subcutaneous injection,while the model group received intervention of an equal amount of double distilled water by gavage for one week. Hematoxylin eosin(HE) staining and small animal Doppler color ultrasound were used to observe the size of thrombus formation in mice. The protein expressions of cleaved cysteine aspartate protease 1 p20(Caspase-1 p20) and gasdermin D N-terminal fragment(GSDMD-N) in peripheral blood mononuclear cells(PBMCs) of mice were detected by Western blot. Enzyme linked immunosorbent assay(ELISA) was used to detect the expression of serum interleukin-1β(IL-1β) and interleukin-18(IL-18). A total of 10 C57 BL/6J mice were selected to prepare Xiaoshuan Tongmai Decoction-containing serum for cell experiments. Lipopolysaccharide(LPS) and adenosine triphosphate(ATP) were used to induce pyroptosis of dendritic cells(DC2.4) in mice,and the DC2.4 cells were divided into dimethyl sulfoxide(DMSO) group,LPS+ATP+blank serum group,and LPS+ATP+high-dose Xiaoshuan Tongmai Decoction-containing serum group. Western blot was used to detect the protein expression of phosphorylated(p)-JAK1,p-STAT1,Caspase-1 p20,and GSDMD-N in DC2.4,and ELISA was used to detect the protein expression of IL-1β and IL-18 in the cell supernatant. Another 15 C57 BL/6J mice were randomly divided into a sham-operation group,a model group,and a high-dose Xiaoshuan Tongmai Decoction group,with 5 mice in each group. After gavage intervention,blood was collected,and Western blot was used to detect the protein expression of p-JAK1,p-STAT1,Caspase-1 p20,and GSDMD-N in the PBMCs of mice. Another 15 mice were randomly divided into 3 groups(5 mice in each group),namely a model group,a high-dose Xiaoshuan Tongmai Decoction+Vector group,and a high-dose Xiaoshuan Tongmai Decoction+pcDNA3.1-mJAK1-3×Flag-C group. The length and mass of thrombus in mice were measured. Results:Compared with the model group,the thrombus formation in the low-dose group of Xiaoshuan Tongmai Decoction,high-dose group of Xiaoshuan Tongmai Decoction,and western medicine group was significantly reduced,and the expression levels of Caspase-1 p20,GSDMD-N,IL-1β,and IL-18 decreased(P<0.01). Compared with the LPS+ATP+blank serum group,the protein expression levels of p-JAK1,p-STAT1,Caspase-1 p20,GSDMD-N,IL-1β,and IL-18 in the LPS+ATP+high-dose Xiaoshuan Tongmai Decoction-containing serum group decreased(P<0.05 or P<0.01). Compared with the model group,the protein expression of p-JAK1,p-STAT1,Caspase-1 p20,and GSDMD-N in the high-dose Xiaoshuan Tongmai Decoction group decreased(P<0.01). Compared with the model group,the length and mass of thrombus in the high-dose Xiaoshuan Tongmai Decoction+Vector group decreased(P<0.01). Compared with the high-dose Xiaoshuan Tongmai Decoction+Vector group,the length and mass of thrombus in the high-dose Xiaoshuan Tongmai Decoction+pcDNA3.1-mJAK1-3×Flag-C group increased(P<0.01). Conclusion:Xiaoshuan Tongmai Decoction treats DVT by inhibiting the JAK1/STAT1 signaling pathway,thereby reducing DC pyroptosis.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 2247K]

Mechanism of Zisheng Shenqi Pill（资生肾气丸）-Containing Serum in Intervening Synovial Cells of Gouty Arthritis Model Based on TNF-α/NLRP3/IL-18 Signaling Pathway
LIANG Lanyun;FAN Jiayi;CHEN Xin;LI Wenhao;JIANG Xuelian;HAN Jieru;Heilongjiang University of Chinese Medicine;Guizhou University of Chinese Medicine;
Objective:To investigate the regulatory effect of Zisheng Shenqi Pill（资生肾气丸）-containing serum on NOD-like protein receptor 3(NLRP3) in synovial cells of gouty arthritis(GA) model,and to clarify its potential mechanism of action from tumor necrosis factor-α(TNF-α)/NLRP3/interleukin-18(IL-18) signaling pathway. Methods:Monosodium urate crystals(MSU) crystals were added to the culture medium of primary rat synovial cells to establish in vitro cell model of GA. The experimental cells were divided into a blank group,a model group,and low-,medium-,and high-dose Zisheng Shenqi Pill-containing serum groups. The 3-(4,5-dimethylthiazol-2)-2,5-diphenyltetrazolium bromide(MTT) method was used to detect the changes in cell proliferation and activity in each group at 24 h. The enzyme-linked immunosorbent assay(ELISA) was used to detect the contents of TNF-α and IL-18 in the cell culture supernatant. Reverse transcription-polymerase chain reaction(RT-PCR) was used to detect the expression levels of TNF-α and IL-18 mRNA in the cells. Western blotting(WB) was used to detect the expression levels of NLRP3 and procaspase-1 proteins in the cells. Results:Compared with the model group,both the low-and high-dose Zisheng Shenqi Pill-containing serum groups significantly inhibited MSU-induced abnormal synovial cell proliferation(P<0.05). Levels of TNF-α and IL-18 in the model group were markedly elevated compared with the blank group(P<0.01). All Zisheng Shenqi Pill-containing serum groups showed significantly reduced levels of TNF-α and IL-18 compared with the model group(P<0.05),with the high-dose group outperforming low-and medium-dose groups(P<0.05). TNF-α and IL-18 mRNA expression was significantly upregulated in the model group compared with the blank group(P<0.01). All Zisheng Shenqi Pill-containing serum groups exhibited significant downregulation of TNF-α and IL-18 mRNA compared with the model group(P<0.05 or P<0.01). Pro-Caspase-1 and NLRP3 protein expression was significantly upregulated in the model group compared with the blank group(P<0.01). Medium-and high-dose Zisheng Shenqi Pill-containing serum groups downregulated Pro-Caspase-1、NLRP3 protein expression compared with the model group(P<0.05). Conclusions:Zisheng Shenqi Pill-containing serum can effectively inhibit MSU-induced abnormal synovial cell proliferation. Its mechanism of action may be closely related to the regulation of the TNF-α/NLRP3/IL-18 signaling pathway. Zisheng Shenqi Pill-containing serum inhibits TNF-α expression,which in turn downregulates NLRP3 and Pro-Caspase-1 protein expression,ultimately reducing the production and release of the downstream potent pro-inflammatory factor IL-18,blocking the inflammatory cascade reaction and exerting an anti-inflammatory effect.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 2116K]

Study on Characteristic,Microscopic and Fluorescence Identification of Tiandong(Asparagi Radix) and Its Adulterants Asparagus Taliensis and Asparagus Munitus
LI Changxin;WANG Yunjia;LIU Song;SU Qiuyu;GE Fucun;FENG Shuai;LI Feng;Shandong University of Traditional Chinese Medicine;Shandong Baiweitang Chinese Herbal Pieces Co.,Ltd.;
Objective:To provide a basis for the identification of Tiandong(Asparagi Radix) through a systematic identification study of Tiandong,Asparagus taliensis and Asparagus munitus. Methods:Comparative studies were carried out on Tiandong,Asparagus taliensis and Asparagus munitus using characteristic,microscopic and fluorescence identification methods. Results:The macroscopic characteristics of Tiandong,Asparagus taliensis and Asparagus munitus are similar. The key point of microscopic identification is the presence or absence of stone cells. There arenumerous stone cells in the crosssection and powder of Tiandong. Asparagus taliensis only has a few stone cells outside the endodermis,while Asparagus munitus has no stone cells. The fluorescence phenomena of the three are similar under an ultraviolet lamp(365 nm) by the traditional fluorescence method. There is also no obvious difference among the three in the two-dimensional fluorescence spectrum,but in the three-dimensional fluorescence spectrum,there are significant differences in the number,peak position and peak intensity of fluorescence peaks. Conclusion:The three-dimensional fluorescence spectrum method combined with the microscopic identification method can effectively identify Tiandong,Asparagus taliensis and Asparagus munitus.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 2751K]

Molecular Identification of A Medicinal Fungus and Its Host from Tianmeng Mountain
SUN Yan;ZHAO Jinlong;ZHANG Kefan;ZHOU Zhongyang;WANG Houwei;Shandong University of Traditional Chinese Medicine;
Objective:To determine the species of a medicinal fungus and its host collected from Tianmeng Mountain. Methods:The collected fungus samples were subjected to isolation,purification,and morphological observation. The isolated and purified colonies were further identified by molecular identification. Morphological and molecular identification was also performed on the host. Results:The morphological characteristics of the medicinal fungus were similar to those of Cordyceps militaris. Its internal transcribed spacer(ITS) barcode sequence showed a similarity of ≥99% with the known genome of Cordyceps militaris in the DNA sequence database(GenBank). The results of cluster analysis showed that it clustered in the same branch as Cordyceps militaris. The morphological characteristics of the host were difficult to distinguish. The cytochrome C oxidase I(COI) barcode sequence showed a similarity of ≥99% with the known Fentonia ocypete genome in GenBank. The clustering analysis results showed that it clustered in the same branch as Fentonia ocypete. Conclusions:Based on morphological and molecular biological identification,the fungus samples collected from Tianmeng Mountain were identified as Cordyceps militaris(L.ex Fr.) Link.(Family:Clavicipitaceae;Genus:Cordyceps). The hosts were identified as Fentonia ocypete(Family:Notodontidae;Genus:Fentonia). This study clarified the original source of the medicinal fungus from Tianmeng Mountain,providing a basis for guiding local folk medicine use in the area and laying a foundation for the development and utilization of this medicinal fungus.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 2688K]

Textual Research on Gaozhi in Traditional Chinese Medicine
TIAN Xinyang;WANG Chunyan;Institute of Chinese Medicinal Literature and Culture,Shandong University of Traditional Chinese Medicine;
The original meanings of Gao and Zhi are fat and grease. The combination of these two characters first appeared in the Formulas for Fifty-two Diseases and has become a commonly used term in traditional Chinese medicine(TCM). Through a comprehensive analysis of relevant literature on Gaozhi,this paper traces the original meanings of the two characters,identifies the differences between them,and sorts them out from different perspectives of physiological Gaozhi,pathological Gaozhi and medicinal Gaozhi based on their specific applications in TCM. Physiological Gaozhi can not only act on the human body as refined substances but also exist in certain parts of the body. Pathological Gaozhi is related to various diseases such as obesity,Xiaodan,and Gaodan. When used as the names of medicinal substances,Gaozhi can be divided into animal and plant types. The evolution process of the term Gaozhi not only enriches the semantic implications but also contributed to the theoretical framework of TCM,offering valuable insights for the clinical treatment of relevant diseases.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1976K]

Study on Place Name Origins in “What Shizhen Said” for Newly Added Drugs in Compendium of Materia Medica
LYU Yangyi;NING Jing;Beijing University of Chinese Medicine;
This study examines place names referenced in “What Shizhen Said” sections for newly added drugs in the Compendium of Materia Medica to investigate whether these additions resulted from LI Shizhen's field investigations. Place name origins are categorized into two types:those sourced from texts cited in “ What Shizhen Said ” and those from uncited texts. Sentences containing place names were traced to explore their origins through contextual analysis,frequency of occurrence,and geographical distances. The study finds that place names in “What Shizhen Said” are numerous and geographically diverse,covering 23 Chinese provinces(autonomous regions and municipalities directly under the Central Govern-ment) and multiple overseas locations,though pre-dominantly derived from textual research. Ancient,overseas place names,and those with contexts traceable to other literature(with minimal content variation) originate from textual sources. Frequently occurring untraceable place names and those documenting growth and morphology of new drugs likely reflect LI Shizhen's field investigations. Most newly added drugs predate the Compendium of Materia Medica in earlier literature,and are not first discovered by LI Shizhen. LI Shizhen compiled content from multiple texts while inconsistently attributing sources(single citation or no attribution). Non-cited portions of “What Shizhen Said” contain material traceable to other texts,warranting further investigation.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1924K]

Research Review of HUANG Yuanyu's Four Sages on the Source of Life
WANG Yunshu;SONG Yongmei;Shandong University of Traditional Chinese Medicine;
Four Sages on the Source of Life is the representative work of HUANG Yuanyu,a renowned physician of the Qing dynasty. In recent years,scholars' research on Four Sages on the Source of Life mainly focuses on three aspects:medical theory,characteristics of syndrome differentiation and treatment,and medical philosophy. Theoretical aspects focus on the physiological and pathological concepts of “one-qi circulation” and “middle qi as the pivot”,as well as the diagnostic and therapeutic ideas of emphasizing yang and the transformation of qi into the six meridians. In terms of clinical practice,HUANG Yuanyu emphasized the importance of pulse diagnosis. The pathogenesis he stressed was “cold water,damp earth,and stagnant wood”. His medication mainly aimed at strengthening the middle jiao and regulating qi,and he was skilled in using classic formulas. At the philosophical level,he integrated Confucian and Taoist thoughts,using the principles of the Yi-ology to explain medical principles. Based on the current research,there is still much to be explored regarding the cultural origin,philosophical connotations,and historical evaluation of HUANG Yuanyu's medical thoughts. It is urgent to conduct a comprehensive study of his academic system from multiple perspectives. There are 50 references in total.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1913K]

Research Overview of Wuzi Yanzong Pill(五子衍宗丸) in Treatment of Oligoasthenospermia
ZHAI Jing;PENG Yu;XU Xinyu;DING Guanxiong;WANG Yizhou;ZHU Wenhui;HOU Jiangang;Department of Urology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine;Department of Urology,Huashan Hospital Affiliated to Fudan University;Department of Urology,Changshu Second People's Hospital;
Oligoasthenospermia is a primary type of male infertility,characterized by deficiency in nature and excess in superficiality. Specifically,kidney deficiency is considered the root cause,often accompanied by spleen deficiency,liver depression,phlegm-dampness,and blood stasis. Wuzi Yanzong Pill（五子衍宗丸） is widely used in the clinical treatment of oligoasthenospermia due to their proven efficacy. Contemporary clinicians employ modified Wuzi Yanzong Pill,empirical formulas and Chinese patent medicines containing Wuzi Yanzong Pill,as well as the combination of formulas containing Wuzi Yanzong Pill with other methods(such as western medicine,acupuncture,moxibustion,etc.),all of which have yielded significant therapeutic benefits. Mechanistic investigations have confirmed that Wuzi Yanzong Pill and its constituent medicines improve testicular spermatogenesis via regulation of the hypothalamic – pituitary – testicular axis,suppression of inflammation and oxidative stress,and modulation of cell proliferation,autophagy,and apoptosis. There are 38 references in total.
2025 06 v.49;No.277 [Abstract][OnlineView][Download 1966K]

2025 06 v.49;No.277 [Abstract][OnlineView][Download 1841K]

下载本期数据